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For information on this subject from a real world perspective, see the Wikipedia page

Cancer is a disease that can be contracted through various means within various parts of the body. Depending on the severity, it can be treated, but success of eliminating it is not guarenteed, at which point it can kill.

In the Light Mobius reality, Locke had, at some point, contracted pancreatic cancer and, despite undergoing surgery, became terminal. He passed away in his sleep on Day 61, 3246. (StH: #143)

Background Information

  • Of the known diseases to appear in the Archieverse, this is the only one that also exists in the real world.